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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
35.45
Human Site:
Y1249
Identified Species:
55.71
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
Y1249
R
T
L
F
S
T
H
Y
H
S
L
V
E
D
Y
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
Y1249
R
T
L
F
S
T
H
Y
H
S
L
V
E
D
Y
Dog
Lupus familis
XP_531814
1283
145094
M1193
R
L
G
H
M
A
C
M
V
E
N
E
C
E
D
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
Y1247
R
T
L
F
S
T
H
Y
H
S
L
V
E
D
Y
Rat
Rattus norvegicus
XP_002726765
1361
151628
Y1250
R
T
L
F
S
T
H
Y
H
S
L
V
E
D
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
Y1355
R
T
L
F
S
T
H
Y
H
S
L
V
E
D
Y
Frog
Xenopus laevis
NP_001089247
1340
149481
Y1231
R
T
L
F
S
T
H
Y
H
S
L
V
E
D
H
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
Y1258
R
T
L
F
S
T
H
Y
H
S
L
V
E
D
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
T1103
N
E
D
N
A
D
P
T
Q
E
T
V
T
F
L
Honey Bee
Apis mellifera
XP_392346
1120
127429
A1033
N
N
K
K
I
T
L
A
H
M
A
C
M
V
E
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
V1099
L
A
H
M
K
C
V
V
D
K
E
N
N
E
D
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
Y1225
R
T
L
F
S
T
H
Y
H
S
L
V
E
E
F
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
C1197
Y
R
L
R
P
G
A
C
P
K
S
Y
G
V
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
Y1198
R
G
F
F
S
T
H
Y
H
R
L
S
V
D
Y
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
I1155
M
C
G
I
S
K
E
I
I
D
N
A
Q
I
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
100
6.6
N.A.
100
100
N.A.
N.A.
100
93.3
93.3
N.A.
6.6
13.3
0
86.6
P-Site Similarity:
100
N.A.
100
13.3
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
13.3
13.3
6.6
100
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
66.6
6.6
N.A.
P-Site Similarity:
6.6
N.A.
N.A.
66.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
7
7
7
7
0
0
7
7
0
0
7
% A
% Cys:
0
7
0
0
0
7
7
7
0
0
0
7
7
0
0
% C
% Asp:
0
0
7
0
0
7
0
0
7
7
0
0
0
54
14
% D
% Glu:
0
7
0
0
0
0
7
0
0
14
7
7
54
20
7
% E
% Phe:
0
0
7
60
0
0
0
0
0
0
0
0
0
7
7
% F
% Gly:
0
7
14
0
0
7
0
0
0
0
0
0
7
0
0
% G
% His:
0
0
7
7
0
0
60
0
67
0
0
0
0
0
14
% H
% Ile:
0
0
0
7
7
0
0
7
7
0
0
0
0
7
0
% I
% Lys:
0
0
7
7
7
7
0
0
0
14
0
0
0
0
0
% K
% Leu:
7
7
60
0
0
0
7
0
0
0
60
0
0
0
7
% L
% Met:
7
0
0
7
7
0
0
7
0
7
0
0
7
0
0
% M
% Asn:
14
7
0
7
0
0
0
0
0
0
14
7
7
0
7
% N
% Pro:
0
0
0
0
7
0
7
0
7
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
7
0
0
0
7
0
0
% Q
% Arg:
67
7
0
7
0
0
0
0
0
7
0
0
0
0
0
% R
% Ser:
0
0
0
0
67
0
0
0
0
54
7
7
0
0
0
% S
% Thr:
0
54
0
0
0
67
0
7
0
0
7
0
7
0
0
% T
% Val:
0
0
0
0
0
0
7
7
7
0
0
60
7
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
0
0
0
0
0
0
60
0
0
0
7
0
0
40
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _